The Future of Business Schools: Purpose, Action, and Impact

Are business schools on the wrong track? For many years, business schools enjoyed rising enrollments, positive media attention, and growing prestige in the business world. However, due to the disruption of Covid-19, many previously ignored issues relating to MBA programs resurfaced. As a result, MBA programs now face lower enrollments and intense criticism for being deficient in preparing future business leaders and ignoring essential topics like ethics, sustainability, and diversity and inclusion. The Future of Business Schools discusses these issues in the context of three critical areas: complexity, sustainability, and destiny. How do we prepare students for a new and complex world, how can business schools focus on the planet's sustainability, and how will they shape a better future for everyone? The chapters present views and suggestions of business school professors, researchers, and leaders from different contexts and countries as well as ideas for business school stakeholders, on topics from program structures, course content, and teaching materials to research topics. In addition to examples of innovations, there are tools offered to help universities navigate complexity and prepare for uncertainty. The material will assist business school faculty, staff, and administrators as well as professionals, policymakers, and organizations in identifying new directions for business schools in this evolving field. © Rico J. Baldegger, Ayman El Tarabishy, David B. Audretsch, Dafna Kariv, Katia Passerini and Wee-Liang Tan 2022. All rights reserved.

Prevalence of Potential Drug-Drug Interactions with Ritonavir-Containing Covid-19 Medications among the Adult Patient Population in Australia: Analysis of Pharmaceutical Benefits Scheme 10% Sample (Pbs10) Claims

Intro: Oral antiviral agents with differing modes of action are now available for the treatment of COVID-19. However, potentially life-threatening drug-drug interactions (DDIs) may occur if patients' underlying co-morbidities are treated with medications that are contraindicated with ritonavir-containing antivirals. This study evaluated the prevalence and severity of potential DDIs (pDDIs) with ritonavir-containing COVID-19 oral antiviral therapy among the Australian population. Method(s): Adult patients supplied with >=1 medication between January 1, 2019, and December 31, 2019, were identified in the PBS10 dataset, a longitudinal, random 10% sample of the national Pharmaceutical Benefits Scheme (PBS) data for supplied prescriptions. Patients receiving medications that have pDDIs with a ritonavir-containing COVID-19 antiviral treatment were classified as the pDDI group, using data sources from University of Liverpool, Lexicomp, or the US Food and Drugs Administration. Finding(s): Over 1,434,000 patients in the PBS10 were supplied with >=1 medication during the study period. The majority (58.8%) had been prescribed at least one medication with pDDI with ritonavir-containing treatment. Among all patients with pDDIs, 43.3% of them were major or contraindicated, followed by moderate (15.1%), and minor pDDIs (1.9%). Patients with cancer had the highest prevalence of contraindicated or major pDDIs (79.5%), followed by dementia and/or Alzheimer's (77.2%), and diabetes (73.8%). Elderly patients (>=60 years old) also had a higher prevalence of contradicted or major pDDI (65.4%) than the general patient population. Conclusion(s): Our results demonstrated that one-third of the Australian adult population in the PBS10 dataset may be classified as contraindicated with ritonavir-containing COVID-19 therapies. The prevalence of pDDI is much higher in elderly patients and in patients with certain co-morbidities. Health care providers will need to evaluate patients carefully should they be eligible for COVID-19 oral antiviral treatments. Alternative therapies should be considered as patients may be precluded from being treated with ritonavir-containing therapies owing to pDDIs.Copyright © 2023

ANTIBIOTIC POINT PREVALENCE SURVEY DURING THE PANDEMIC IN A COVID-19 DESIGNATED HOSPITAL IN MALAYSIA

Recent reports have shown that antibiotics were commonly prescribed in COVID-19 designated hospitals throughout the pandemic in spite of it being ineffective in treating viruses such as SARS-COV 2 which is the pathogen responsible for causing COVID-19. We conducted a cross-sectional Point Prevalence Survey (PPS) involving all wards in Hospital Sungai Buloh. Each ward was audited within one day within the period of two weeks (1st December 2021 till 14th December 2021). All in-patients receiving IV or oral antibiotics at 8am on the day of survey were included in the study. A total of 200 out of 664 in-patients (30%) were treated with antibiotics during the study period. COVID ICU recorded the highest prevalence of patient on antibiotics (83%) followed by General Medical (43%). Majority of patients received antibiotics for empirical therapy (80%, 160/200) and community-acquired pneumonia was the most common indication documented (36.5%, 75/205), followed by hospital-acquired pneumonia, with 23.4% of total documented indication (48/205). We found that in half of the patients (104/200), clinicians did not document the indication of antibiotic. Rate of prescription that was compliant to guideline was higher than that of non-compliant to guideline from total of 139 cases recorded (68% vs 32%). We found that there was a significant association between rate of compliant to guideline with respiratory diseases (χ² = 5.37, p<0.05). Twenty-seven percent of patients received antibiotics for respiratory diseases not according to guideline recommendation. Majority of cases of non-compliance to guideline, were patient with respiratory diseases (58.7%, 27 out of 46 cases). This pandemic has had an impact on the use of antibiotics, where its use has been found to increase drastically, especially in critical and severe patients. This high use makes adherence to the guidelines become important and should be an ongoing indicator, also it can be used as a guide for antimicrobial stewardship intervention. [ FROM AUTHOR] Copyright of International Journal of Infectious Diseases is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

Robust autoregressive modeling and its diagnostic analytics with a COVID-19 related application

Autoregressive models in time series are useful in various areas. In this article, we propose a skew-t autoregressive model. We estimate its parameters using the expectation-maximization (EM) method and develop the influence methodology based on local perturbations for its validation. We obtain the normal curvatures for four perturbation strategies to identify influential observations, and then to assess their performance through Monte Carlo simulations. An example of financial data analysis is presented to study daily log-returns for Brent crude futures and investigate possible impact by the COVID-19 pandemic. © 2023 Informa UK Limited, trading as Taylor & Francis Group.

Evaluation of patients with history of vaccine allergies prior to mRNA-based Coronavirus Disease 2019 (COVID-19) vaccination

Background: During the initial rollout of COVID-19 vaccination in Singapore, the Ministry of Health (MOH) issued recommendations that patients with a history of any previous vaccine allergy be referred to an allergist for further review on suitability to proceed with mRNA-based COVID-19 vaccines. We review the evaluation of these patients with suspected vaccine allergies prior to receiving mRNA-based COVID-19 vaccines. Method(s): Between 8 April and 22 September 2021, 304 patients were evaluated prior to receiving the COVID-19 vaccinations. Of these, 63 (20.7%) patients with suspected immediate hypersensitivity reactions to non-COVID polysorbate-containing vaccines proceeded to have skin prick test (SPT) and Intradermal test (IDT) to polyethylene glycol (PEG)-3350, polysorbate 80 and polysorbate 20 containing products. Another 62 (20.4%) who reported delayed hypersensitivity reactions to polysorbate-containing vaccines proceeded to have direct inoculation (DI) of the Pfizer BNT162b2 vaccine under the supervision of an allergist. The remaining 242 (76.6%) finally assessed not allergic polysorbate-or tolerated previous non-polysorbate- containing vaccines were recommended to proceed with COVID-19 vaccinations at the community vaccination sites. 99 patients in the SPT/IDT and DI group completed a questionnaire-based survey to report any post vaccination reactions. (Figure 1) Results: Of 63 patients who underwent SPT/IDT, 2 (3.2%) with equivocal IDT tolerated both doses of the BNT162b2 vaccine without major allergic reactions. 61 (6.8%) patients with negative SPT/IDT and 62 (100%) in the DI group completed both doses of BNT162b2 vaccination without major reactions. Among those who completed the questionnaire survey, 13 (13%) reported reactions including non-specific rashes and mild urticaria/angioedema post first dose vaccine. All subsequently completed the second dose of the BNT162b2 vaccine following allergist review;with 8 (61.5%) reporting similar mild skin reactions. Conclusion(s): Majority of those with suspected reactions to polysorbate containing vaccines are able to tolerate the BNT162n2 vaccine which contains PEG-2000. Skin tests prior to mRNA COVID-19 vaccination is unnecessary. Those who report mild potentially allergic reactions after the first dose are able to tolerate the second dose of the BNT162b2 vaccine.

Two-Stage COVID19 Classification Using BERT Features

We propose an automatic COVID1-19 diagnosis framework from lung CT-scan slice images using double BERT feature extraction. In the first BERT feature extraction, A 3D-CNN is first used to extract CNN internal feature maps. Instead of using the global average pooling, a late BERT temporal pooing is used to aggregate the temporal information in these feature maps, followed by a classification layer. This 3D-CNN-BERT classification network is first trained on sampled fixed number of slice images from every original CT scan volume. In the second stage, the 3D-CNN-BERT embedding features are extracted for every 32 slice images sequentially, and these features are divided into fixed number of segments. Then another BERT network is used to aggregate these features into a single feature followed by another classification layer. The classification results of both stages are combined to generate final outputs. On the validation dataset, we achieve macro F1 score 92.05%;and on the testing dataset, we achieve macro F1 84.43%. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

The application of emotions, sharing motivations, and psychological distance in examining the intention to share COVID-19-related fake news

Purpose: Coronavirus disease 2019-related fake news consistently appears on social media. This study uses appraisal theory to analyze the impact of such rumors on individuals' emotions, motivations, and intentions to share fake news. Furthermore, the concept of psychological distance and construal level theory are used in combination with appraisal theory to compare toilet paper shortages and celebrity scandal rumors. Design/methodology/approach: Data collected from 299 Taiwanese respondents to 150 toilet paper shortage-related and 149 celebrity gossip-related questionnaires were processed using partial least squares regression and multigroup analysis. Findings: In both cases, surprise is felt most intensely. However, unlike in the celebrity fake news scenario, worry plays a prominent role in driving the altruistic sharing motivation related to the toilet paper shortage rumor. Furthermore, while emotional attributes (basic or self-conscious, concrete, or ) serve as a guide for how emotions change with psychological distance, the degree to which an emotion is relevant to the fake news context is key to its manifestation. Originality/value: This study examines the impact of individuals' emotions on their motivations and intention to share fake news, applying the appraisal theory and the psychological distance concept in a single study to fake news sharing intention. It evaluates the relationship between psychological distance and emotions, revealing that it is not absolute and need not necessarily shift according to psychological distance change;rather, the relationship is context-sensitive. © 2022, Emerald Publishing Limited.

Experience with MDA5 positive myositis

Introduction and Objective: Idiopathic inflammatory myopathies(IIMs) is a group of autoimmune disease characterized by muscular and extra-muscular manifestation. IIMs with anti-MDA5 antibody positivity carries poor prognosis due to rapid progressive interstitial lung disease (RP-ILD). We report clinical course of patients cared in our centre. Method(s): Patients medical record were reviewed for data collection. Result(s): Four patients with MDA5 antibody positive IIMs following up in our clinic (Table 1). None has reported Covid infection. Two has respiratory disease responded to induction therapy. One still undergoing titration of immunosuppressant. One female patient presented unwell with pleural effusion and acute pneumonitis. Patient later developed rapid progression of interstitial lung inflammation with refractory supraventricular tachycardia. IVIG was initiated, however she succumbed to adult respiratory distress syndrome (ARDS) due to pneumonia. Plasma exchange was not carried out due to source limitation at that time of period. Conclusion(s): Prevalence of anti MDA-5 positive is 30%-50% in Asians patients with IIMs particularly the east. However, it is likely under-reported in Malaysia due to lack of understanding of the pattern of disease in our multiracial population as well as lack of myositis serology tests availability especially in government hospitals. Research and registry should be instituted to allow better study of this disease in our population, to better the treatment and reduce morbidity and mortality due to rapid progressing interstitial lung disease. (Table Presented).

Regression Study on Influencing Factors of COVID-19 Diagnosis Rate and Mortality: A Global Perspective

The novel coronavirus pneumonia (COVID-19) refers to the pulmonary infection caused by the novel coronavirus (2019-nCoV), which has become an urgent public health event of global concern at present. In order to help local governments to find out the factors that curb the spread of COVID-19, we explored the influence factors that cause COVID-19 infection and death in the fields of economy, society, life, and health in this paper. Through correlation analysis, we found that COVID-19 transmission and mortality are relatively strongly associated with human development index (HDI), Median Age, human life expectancy, proportion of smokers, and GDP per capita. Further regression analysis and machine learning regression algorithms also confirmed that HDI, proportion of smokers, GDP per capita, and Median Age have significant effects on COVID-19 transmission and mortality, with GBDT performing best with R² of 0.585 and 0.415 per million confirmed cases and deaths, respectively. This study aims to explore the impact of relevant factors on COVID-19 in the international community, inform the development of measures to reduce diagnosis and mortality rates in countries, and improve the capacity to respond to such public health emergencies. © 2022 ACM.

Monkeypox awareness, knowledge, and attitude among undergraduate preclinical and clinical students at a Malaysian dental school: An emerging outbreak during the COVID-19 era

Objective: To evaluate the awareness, knowledge, and attitude on monkeypox viral infection among preclinical and clinical dental students in Malaysia. Methods: A cross-sectional study was conducted among 229 preclinical and clinical dental students via an online self-reported questionnaire. The questionnaire included 3 items on awareness, 15 items on knowledge, 9 items on attitude and 2 open-ended questions. Data were presented as frequencies and percentages. Chi-square test was used to compare knowledge and awareness scores between preclinical and clinical dental students and content analysis was performed for open-ended responses. Results: Preclinical and clinical dental students were aware of the existence of monkeypox (89.5% and 94.4%, respectively), that the disease emerged in non-endemic countries (81.0% and 87.1%, respectively) and that it was declared a public health emergency of international concern by the World Health Organization (73.3% and 79.0%, respectively). Clinical dental students' overall knowledge level was significantly higher than preclinical dental students (P=0.014). Both preclinical (95.2%) and clinical (96.8%) dental students demonstrated positive attitudes toward monkeypox with no significant difference (P=0.736) noted between them. Three themes emerged from the open-ended questions: (1) reimplementation of nationwide lockdown, (2) impact on the economy and health, and (3) disruption to the educational system. Students also anticipated their face-to-face learning to be reduced should there be a new outbreak. Conclusions: Both preclinical and clinical dental students showed comparable awareness and attitudes, while the latter demonstrated greater satisfactory knowledge toward the re-emergence of monkeypox during the COVID-19 pandemic. Nonetheless, efforts to improve dental students' understanding of this alarming outbreak are required, to safeguard their health and minimise transmission.

Use of a Cytosponge biomarker panel to prioritise endoscopic Barrett's oesophagus surveillance: a cross-sectional study followed by a real-world prospective pilot.

BACKGROUND: Endoscopic surveillance is recommended for patients with Barrett's oesophagus because, although the progression risk is low, endoscopic intervention is highly effective for high-grade dysplasia and cancer. However, repeated endoscopy has associated harms and access has been limited during the COVID-19 pandemic. We aimed to evaluate the role of a non-endoscopic device (Cytosponge) coupled with laboratory biomarkers and clinical factors to prioritise endoscopy for Barrett's oesophagus. METHODS: We first conducted a retrospective, multicentre, cross-sectional study in patients older than 18 years who were having endoscopic surveillance for Barrett's oesophagus (with intestinal metaplasia confirmed by TFF3 and a minimum Barrett's segment length of 1 cm [circumferential or tongues by the Prague C and M criteria]). All patients had received the Cytosponge and confirmatory endoscopy during the BEST2 (ISRCTN12730505) and BEST3 (ISRCTN68382401) clinical trials, from July 7, 2011, to April 1, 2019 (UK Clinical Research Network Study Portfolio 9461). Participants were divided into training (n=557) and validation (n=334) cohorts to identify optimal risk groups. The biomarkers evaluated were overexpression of p53, cellular atypia, and 17 clinical demographic variables. Endoscopic biopsy diagnosis of high-grade dysplasia or cancer was the primary endpoint. Clinical feasibility of a decision tree for Cytosponge triage was evaluated in a real-world prospective cohort from Aug 27, 2020 (DELTA; ISRCTN91655550; n=223), in response to COVID-19 and the need to provide an alternative to endoscopic surveillance. FINDINGS: The prevalence of high-grade dysplasia or cancer determined by the current gold standard of endoscopic biopsy was 17% (92 of 557 patients) in the training cohort and 10% (35 of 344) in the validation cohort. From the new biomarker analysis, three risk groups were identified: high risk, defined as atypia or p53 overexpression or both on Cytosponge; moderate risk, defined by the presence of a clinical risk factor (age, sex, and segment length); and low risk, defined as Cytosponge-negative and no clinical risk factors. The risk of high-grade dysplasia or intramucosal cancer in the high-risk group was 52% (68 of 132 patients) in the training cohort and 41% (31 of 75) in the validation cohort, compared with 2% (five of 210) and 1% (two of 185) in the low-risk group, respectively. In the real-world setting, Cytosponge results prospectively identified 39 (17%) of 223 patients as high risk (atypia or p53 overexpression, or both) requiring endoscopy, among whom the positive predictive value was 31% (12 of 39 patients) for high-grade dysplasia or intramucosal cancer and 44% (17 of 39) for any grade of dysplasia. INTERPRETATION: Cytosponge atypia, p53 overexpression, and clinical risk factors (age, sex, and segment length) could be used to prioritise patients for endoscopy. Further investigation could validate their use in clinical practice and lead to a substantial reduction in endoscopy procedures compared with current surveillance pathways. FUNDING: Medical Research Council, Cancer Research UK, Innovate UK.

Evaluation of the performance of two commercial SARS-CoV-2 neutralizing antibody test kits

Objective To evaluate the performance of two commercial EIA kits for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibodies. Methods Two commercial SARS-CoV-2 neutralizing antibody ELISA test kits (A and B) were used to detect serum panel consists of the following sera: 44 collected before vaccination, 120 collected one month after vaccination and 64 collected six months after recovery from convalescent patients of COVID-19. In the meantime, the above samples were also taken for live virus micro-neutralization test (micro-NT) indicated as the 50% neutralization antibody titer (NT50 ) . The consistency of qualitative and quantitative results between the two commercial kits and live virus neutralization test was analyzed. Results Taking the micro-NT results as the standard, the positive coincidence rates of A and B kits were 97. 40% and 100. 00%, respectively;the negative coincidence rates were 97. 30% and 95. 95%, respectively;the Youden indices were 0. 95 and 0. 96, respectively. Furthermore, quantitative analysis indicated that the correlation coefficients between A and B kits and micro-NT results were 0. 24 (P<0. 05) and 0. 52 (P<0. 000 1) for samples collected after vaccination, respectively;while the correlation coefficients were 0. 81 (P<0. 000 1) and 0. 89 (P<0. 000 1) for convalescent serum samples, respectively. Conclusions The results obtained by the two commercial neutralizing antibody detection kits were in good agreement with the qualitative results of micro-NT. The neutralizing antibody titers in convalescent serum samples detected by the two kits showed a stronger correlation with the micro-NT results. © 2022 Society of Microbiology and Immunology. All rights reserved.

Cross-neutralization of antibodies induced by inactivated SARS-CoV-2 vaccine against Beta and Delta variants

Objective To evaluate the in vitro cross-neutralization of serum antibodies in human and mice immunized with inactivated SARS-CoV-2 vaccine against Delta and Beta variants. Methods Human serum samples after a second and a third dose of inactivated SARS-CoV-2 vaccine and mouse serum samples after a two-dose vaccination were collected. The neutralizing antibodies in the samples against SARS-CoV-2 strains of prototype, Delta and Beta variants were detected using micro-neutralization assay in biosafety level III laboratory. The seroconversion rates and geometric mean titers (GMTs) of antibodies were calculated. Results The seroconversion rates of antibodies in human serum samples against different SARSCoV-2 strains were all above 95%. After two-dose vaccination, the GMTs of neutralizing antibodies against the prototype, Delta and Beta strains were 109, 41 and 15, respectively. The GMTs decreased by 2. 7 folds and 7. 3 folds for the Delta and Beta variants as compared with the prototype strain. After the booster vaccination, the GMTs of neutralizing antibodies against the prototype, Delta and Beta strains were 446,190 and 86, respectively. The GMTs of neutralizing antibodies against Delta and Beta variants decreased by 2. 3 folds and 5. 2 folds as compared with that against the prototype strain. The seroconversion rates of antibodies against different SARS-CoV-2 strains in mouse serum samples were all 100%. The GMTs of neutralizing antibodies against the prototype, Delta and Beta strains were 2 037, 862 and 408, respectively. The GMTs decreased by 2.4 folds and 5.0 folds for the Delta and Beta variants. Conclusions Inactivated SARS-CoV-2 vaccine could induce a certain level of neutralizing antibodies against Delta and Beta variants in both human and mouse models. Moreover, a third dose of vaccine induced higher levels of neutralizing antibodies against Delta and Beta variants in human. This study provided valuable data for the clinical application and protective evaluation of the inactivated SARS-CoV-2 vaccine.

New Insights from Chemical Biology: Molecular Basis of Transmission, Diagnosis, and Therapy of SARS-CoV-2

Coronavirus disease 2019 (COVID-19) is caused by a novel strain of coronavirus, designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It has caused a global pandemic rapidly sweeping across all countries, bringing social and economic hardship to millions. Most countries have implemented early warning measures to detect, isolate, and treat patients infected with SARS-CoV-2. This minireview summarizes some of those steps, in particular, testing methods and drug development in the context of chemical biology, and discusses the molecular basis of COVID-19's virulent transmissibility.

Land Subsidence Monitoring in Wuhai City Based on D-InSAR

Wuhai City is an important coal resource area in Inner Mongolia Autonomous Region. High-intensity underground mining will cause large land subsidence. Differential SAR Interferometry (D-InSAR) is a popular monitoring method of land subsidence in recent years. This paper uses two-pass D-InSAR method to monitor land subsidence in Wuhai City. The experimental data selects 7 scenes of C-band Sentinel-1A images from September 2019 to March 2020. The final deformation results are shown in the Figure 3. The two-pass D-InSAR processing flow includes data focusing, baseline estimation, interferogram generation, adaptive filtering and coherence generation, phase unwrapping, orbit refining and re-flattening, deformation map generation. The result shows: During the monitoring time, the most serious subsidence areas are concentrated near the mine clusters on the east and west sides of Wuhai City. Maximum settlement value up to 242 mm. The subsidence values in heavy industrial and residential areas are slightly smaller compared to the former. Settlement values are generally ranged from 56 to 87 mm. The settlement is lightest in the southern part of Hainan district. It indicates that mining can greatly accelerate surface subsidence. Meanwhile, human activities and groundwater extraction can increase subsidence. From the perspective of time, Settlement in Wuhai City is more pronounced during September to December 2019 but it decreases sharply in January 2020.This should be related to the outbreak of COVID-19. The subsidence value increased slightly from February to March 2020, which showed that the epidemic had been preliminarily controlled and people began to return to work.

A Case Study of Social Work Leadership in the Pandemic Intervention in Wuhan

Social workers in Wuhan, China were among the first to respond to the public health crisis caused by Coronavirus disease (COVID-19) in early 2020. Social workers in Wuhan developed and implemented an effective interventional model integrating online and offline volunteers of multiple professions-the '4 + 1' model-to support affected individuals in the process of battling the pandemic. Transformational social work leadership played a vital role in the widely adopted model in China, characterised by idealised influence-attributed (or charisma);idealised influence-behavioural;inspirational motivation;intellectual stimulation and individual consideration. Contextual performance is also discussed, followed by a discussion on why social work can play a leadership role in inter-disciplinary intervention in the pandemic crisis. The article concludes with the areas social workers can improve on for the betterment of leadership.

Reopen Offline Business during a Pandemic? Characterization of Health Certificate Exchange for Human Movement Management

The COVID-19 pandemic has significantly restricted the regular offline business activities. Nevertheless, as certain offline business activities are still indispensable, to conduct offline business under pandemic control becomes a valuable research question. This paper addressed this problem by studying business movement management based on health certificate exchange. We first observed three patterns of health certificate exchange multiplicity that serve as a basis for business movement management. Then, we reviewed published literature along two orthogonal directions, health certificates and exchange systems. We studied different health certificates published during the COVID-19 pandemic to identify the categories of health certificates and their characteristics. Meanwhile, we further studied different design paradigms and characteristics of health certificate exchange systems. Last, we mapped our findings on health certificate exchange into the four challenges of movement management systems in a pandemic, namely flexible controllability, scalable accessibility, adaptive reusability, and spatiotemporal traceability, and conceptualized how such the requirements should be achieved and a complete system should operate. © 2021 IEEE.